It is crucial for dental professionals to acknowledge the interrelationship between periodontics and orthodontics and the potential of integrating both therapies to achieve optimal oral health and esthetics for our patients requiring complex interdisciplinary care. This presentation will delve into the synergistic relationship between periodontics and orthodontics, highlighting the importance of a strong periodontal foundation for successful orthodontic treatment. The discussion will include the various periodontal considerations in orthodontic interdisciplinary treatment planning, specifically for the severe stage III/IV periodontitis patients, intra-treatment phase strategies for monitoring and managing treatment progress, and post treatment phase maintenance and retention. Further, the presentation will also discuss the differing perspectives on periodontal-orthodontic treatment sequence and modalities. Through a blended series of clinical cases, we aim to provide a unique perspective based on our experiences in Hong Kong.