Plaque-induced periodontal diseases are characterised by clinical gingival redness and inflammation, bleeding on probing and if progressive, deeper probing depth, clinical attachment loss, bone loss, increased mobility, and eventual tooth loss. However, different systemic and hormonal conditions such as diabetes mellitus and pregnancy pyogenic granuloma, autoimmune diseases such as lichen planus; pemphigoid, and systemic lupus erythematosus, malignant conditions such as squamous cell carcinoma and other local factors such trauma from occlusion can modify, aggravate, and affect the clinical manifestations of classic gum disease posing challenges to the diagnosis and management. This lecture will discuss these different systemic and local conditions that can affect the clinical manifestation and progression of the "everyday qum disease" and will also suggest ways on its diagnosis and management.